Princess Louise Charlotte of Denmark (30 October 1789 – 28 March 1864) was a princess of Denmark.

She was born in Christiansborg Palace to Hereditary Prince Frederick of Denmark and Norway and Sophia Frederica of Mecklenburg-Schwerin (1758–1794), Princess and Duchess of Mecklenburg-Schwerin.

On 10 November 1810 in Amalienborg Palace she married Landgrave William of Hesse-Kassel. They were parents to:

 Karoline Friederike Marie of Hesse-Kassel (15 August 1811 – 10 May 1829).
 Marie Luise Charlotte of Hesse-Kassel (9 May 1814 – 28 July 1895). Married Prince Frederick Augustus of Anhalt-Dessau.
 Louise of Hesse-Kassel (7 September 1817 – 29 September 1898). Married Christian IX of Denmark.
 Friedrich Wilhelm Georg Adolf, Landgrave of Hesse-Kassel (26 November 1820 – 14 October 1864). Married, first, Grand Duchess Alexandra Nikolaevna of Russia, a daughter of Nicholas I of Russia and Charlotte of Prussia. She died soon after their marriage. He married, second, Princess Anna of Prussia.
 Auguste Sophie Friederike of Hesse-Kassel (30 October 1823 – 17 July 1899. Married Baron Charles Frederick von Blixen-Finecke.
 Sophie Wilhelmine of Hesse-Kassel (18 January – 20 December 1827).

She was described as practical and economic, with some interest for art and poetry, and held a strict economic control over her court. On 18 July 1851, she and her son renounced their claim to the Danish throne to her daughter, who in turn renounced it to her spouse.

Louise Charlotte is the matrilineal great-grandmother of Nicholas II of Russia, William IV, Grand Duke of Luxembourg and George V.

She died in Christiansborg Palace.

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