Vilma Lucila Espín Guillois (April 7, 1930 – June 18, 2007) was a Cuban revolutionary, feminist and chemical engineer. She was married to Raúl Castro, the current Cuban President, who is the brother to former Cuban President Fidel Castro. Espín had four children (Deborah - married to Luis Alberto Rodríguez López-Calleja -, Mariela, Nilsa and Alejandro Castro Espín) and seven grandchildren. Her daughter, Mariela Castro, currently heads the Cuban National Center for Sex Education, and her son, Alejandro Castro Espín, is a Colonel in the Ministry of Interior. Espín was often described as "Cuba's First Lady".

Espín, from Santiago de Cuba, was the daughter of a lawyer for the Bacardi family, Jose Espín and wife Margarita Guillois. She had four siblings, Nilsa, Iván, Sonia and José. In the 1950s, she studied chemical engineering at MIT in Cambridge, Massachusetts before meeting revolutionary leader Frank País in Havana. The meeting led Espín to become a leader of the revolutionary movement in Oriente province. Espín acted as a messenger between the movement and Fidel Castro's 26th of July Movement, which had been relocated to Mexico in order to plan a future invasion. It was in Mexico that Espín met Raúl Castro. She then went on to assist the revolutionaries in the Sierra Maestra mountains after the 26th of July Movement's return to Cuba on the Granma yacht. She and Raúl married in January 1959.

Espín was President of the Federation of Cuban Women from its foundation in 1960 until her death. The organization is a recognized non-government organization which claims a membership of more than three and a half million women, and is generally recognised as a Quango or GONGO. Espín was also a member of the Council of State of Cuba, as well as a member of the Central Committee and the Political Bureau of the Communist Party of Cuba from 1980 to 1991.

Espín headed the Cuban Delegation to the First Latin American Congress on Women and Children in Chile in September 1959. She also headed the Cuban delegations to the Conferences on Women held in Mexico, Copenhagen, Nairobi and Beijing.

Espín died in Havana at 4:14 p.m. EDT on June 18, 2007, following a long illness. An official mourning-period was declared from 8 p.m. on June 18 until 10 p.m. on June 19. Her body was cremated, and her remains rest in the "II Frente Frank País" Mausoleum.
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